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KMID : 0378019810240120113
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New Medical Journal
1981 Volume.24 No. 12 p.113 ~ p.122
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Clinical Observation on the Delayed Neuropsychiatric Sequelae of Carbon Monoxide Intoxication
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Abstract
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The clinical courses of 42 patients admitted in the neuropsychiatric department of National Medical Center suffering from neuropsychiatric sequelae after acute carbon monoxide intoxication were investigated. The findings and results obtained could be summarized as follow:
1) Female overnumbered male by 4 : 3. The cases of age range of 5059 constituted over 33.3% and most of the cases (83.4%) were over 30 years of age.
2) The exposure time to CO gas ranged from 4 to 22 hours. Twenty-two cases (47.6%) were exposed to CO for 6 to 12 hours, and exposure time was obscure in 13 cases (31.00).
3) Most of the cases (69.0%) had been comatose for less than 2 days, and yet one patient, as long as 22 days. Three being resumed from their brief loss of consciousness for less than an hour showed grave signs of sequelae.
4) Cases with lucid interval were 30 (71.400) and predominated over cases without lucid interval (28.600) by 2.5: 1. The incidence of delayed sequelae with lucid interval tended to increase in accordance~ with the age.
5) Lucid interval of delayed sequelae was ranged from 3 to 40 days. Exposure time to CO, duration of coma, and hyperbaric oxygen therapy after acute intoxication were not correlated to make difference on-lucid interval.
6) Most common manifestations of sequelae were memory loss, disorientation, apathy, double incontinence, mutism, hypokinesia, headache, ataxia, insomnia confusion et al. in their
order of frequency.
7) In EEG finding, over 83.8% of cases had EEG abnormalities, more than mild degree,
consisting of 17 Hz slow waves of low voltage, frequently with a frontal and temporal
preponderance. There was no evidence of correlation between severity of EEG abnorma-
lity or improvement of EEG finding and the patient´s physical condition.
8) Since no specific treatment has yet been in practice, supportive and symptomatic mea-
sures are applicable with a respect of spontaneous recovery. Over 59.5% of whole cases
were sufficiently improved on discharge. It needed long duration, this is, 3 weeks to 3
months to recover from sequelae of CO intoxication.
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